Senior Director, Global Medical Affairs

Job Description:

• Lead the global medical affairs strategy and tactical execution plan for cleminorexton
• Serve as Global Medical Affairs Lead and core member of the cross-functional asset team
• Align medical strategy with corporate objectives, clinical development milestones, and commercialization plans
• Establish long-range medical affairs planning for regulatory approvals, launch readiness, and lifecycle management
• Identify emerging scientific opportunities, evidence gaps, and stakeholder needs
• Lead medical launch preparedness activities across major global markets
• Develop integrated launch strategies with commercial, market access, HEOR, regulatory affairs, and regional medical teams
• Align scientific platforms, training content, medical information resources, publications, congress activities, and insights generation with strategy and launch timelines
• Support pre-launch and launch planning, including global payer engagement strategies and value communication
• Build and maintain relationships with global key opinion leaders, investigators, professional societies, and patient advocacy organizations
• Lead scientific advisory boards, expert consultations, and other insight-gathering initiatives
• Represent Centessa at major scientific congresses and industry meetings
• Serve as a scientific ambassador and subject matter expert for orexin biology and sleep-wake disorders
• Partner strategically with commercial, market access, HEOR, regulatory, clinical development, patient advocacy, and corporate affairs
• Contribute medical expertise to brand strategy, payer engagement, disease-state education, and scientific communication initiatives
• Support development of scientific platforms, publication strategies, educational programs, and medical training
• Provide medical review and guidance for externally facing scientific materials in compliance with regulations and company policies
• Report to the Head of Medical Affairs and partner with senior leadership

Requirements:

• Advanced scientific or clinical degree (MD, PharmD, or PhD)
• Minimum 10 years of Medical Affairs leadership experience; 5 years of global experience preferred
• Experience in neuroscience, sleep medicine, neurology, psychiatry, or rare disease
• Demonstrated experience leading at least one successful global product launch
• Experience serving as a global medical lead for late-stage development or commercial products
• Strong understanding of global medical affairs, evidence generation, payer evidence requirements, and commercialization readiness
• Proven ability to drive strategy in a matrix environment
• Proven track record of collaborating with commercial, market access, HEOR, regulatory affairs, and clinical development organizations
• Exceptional communication, presentation, and stakeholder management skills
• Based in the United States
• Approximately 20% travel

Benefits:

• Company bonus depending on company and individual performance
• Company-sponsored 401(k)
• Pension
• Vacation benefits
• Medical, dental, vision, and prescription drug benefits
• Flexible benefits, including healthcare and/or dependent day care flexible spending accounts
• Life insurance and death benefits
• Time off and leave of absence benefits
• Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities
• Remote work arrangement
• Travel opportunities, approximately 20%